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Effects of carbenoxolone sodium on stress‐induced gastric damage in rats
Author(s) -
Perkins W. E.,
Vars L.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08213.x
Subject(s) - carbenoxolone , medicine , endocrinology , pharmacology , sodium , glycyrrhiza , intraperitoneal injection , chemistry , biochemistry , pathology , gap junction , intracellular , alternative medicine , organic chemistry
Carbenoxolone sodium was studied to determine its effect against restraint-induced gastric mucosal damage in the rat. Significant anti-ulcer activity was observed following intraperitoneal administration in nonfasted but not in either 24 or 48 h fasted rats. Orally, carbenoxolone had no statistically significant effect in non-fasted rats although the data suggest that it may have afforded some protection. These results indicate that the use of non-fasted rats is most probably a requirement for demonstrating the protective activity of this type of anti-ulcer compound in stressed rat assays.