Premium
An assessment of sympathetic function in isolated tissues from mice given nerve‐growth‐factor antiserum and 6‐hydroxydopamine
Author(s) -
HUGHES I. E.,
KIRK JENNIFER A.,
KNEEN BARBARA,
LARGE B. J.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08201.x
Subject(s) - hydroxydopamine , nerve growth factor , medicine , endocrinology , stimulation , cholinergic , atropine , sympathectomy , ganglionectomy , chronotropic , chemistry , dopamine , heart rate , pathology , receptor , alternative medicine , dopaminergic , blood pressure
Summary1 Experiments were done on isolated tissues from mice injected with 0·9% w/v NaCl solution (saline), 6‐hydroxydopamine (6‐OHDA), nerve‐growth‐factor antiserum (NGF‐As) or a combination of these agents (NGF‐As 4–6‐OHDA). 2 Fluorescence histochemistry of vasa deferentia showed clear differences between each of the treatments but no such distinction was possible in cardiac ventricle or intestine. 3 Compared with controls, the chronotropic responses of atria to field stimulation were reduced by all three treatments in the order NGF‐As<6‐OHDA