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The effect of desensitization to adenosine triphosphate on the peristaltic reflex in guinea‐pig ileum
Author(s) -
Weston A. H.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08191.x
Subject(s) - peristalsis , adenosine triphosphate , adenosine , desensitization (medicine) , reflex , ileum , guinea pig , muscle contraction , chemistry , medicine , endocrinology , biology , biochemistry , receptor
Contractions of the longitudinal muscle of guinea-pig ileum were inhibited by adenosine triphosphate. This inhibition was prevented by specific desensitization of the tissue to adenosine triphosphate whilst the peristaltic reflex was unaffected. The results suggest that the transmitter substance released from the intramural inhibitory neurones activated during peristalsis is not adenosine triphosphate.