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Effects of prostaglandin E 1 on acid secretion, mucosal histamine content and histidine decarboxylase activity in rat stomach
Author(s) -
HÅKANSON R.,
LIEDBERG G.,
OSCARSON J.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08181.x
Subject(s) - histidine decarboxylase , histamine , pentagastrin , gastrin , medicine , endocrinology , prostaglandin , gastric acid , parietal cell , chemistry , prostaglandin e2 , gastric mucosa , secretion , histidine , stomach , biology , enzyme , biochemistry
Summary1 Prostaglandin E 1 inhibits basal and pentagastrin‐stimulated gastric acid secretion. The mechanism of this action is not clear. One possible explanation might be that prostaglandin E 1 interferes with the local release or synthesis of histamine which has been proposed as the mediator of the effects of gastrin on the parietal cell. 2 A single injection of prostaglandin E 1 did not affect mucosal histamine content or histidine decarboxylase activity in the rat stomach. Pentagastrin lowered the histamine content and activated the histidine decarboxylase to the same extent in prostaglandin E 1 ‐pretreated and in control rats. We conclude therefore that the inhibitory effect of prostaglandin E 1 on basal and pentagastrin‐stimulated acid secretion is not caused by inhibition of histamine release or histamine synthesis. 3 Repeated injections of prostaglandin E 1 resulted in a significant elevation of the gastric histidine decarboxylase activity in normal but not in antrectomized rats. Conceivably, this increase in enzyme activity is secondary to prostaglandin E 1 ‐induced inhibition of acid secretion, which will stimulate release of gastrin due to the rise in intragastric pH.