Premium
The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea‐pig heart
Author(s) -
BASKIN S. I.,
DUTTA S.,
MARKS B. H.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08161.x
Subject(s) - ouabain , inotrope , guinea pig , potassium , chemistry , intracellular , pharmacology , strophanthin , medicine , endocrinology , sodium , biochemistry , organic chemistry
Summary1 Diphenylhydantoin (DPH) and potassium significantly prevent ouabain intoxication without preventing the inotropic effects of ouabain in the guinea‐pig isolated heart. 2 The antiarrhythmic effect of DPH and K on ouabain‐induced toxicity appears to be related to their ability to reduce ouabain accumulation by the myocardium and thereby prevent the intracellular Na and K changes which lead to the arrhythmic state.