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Effect of 2‐diethylaminoethyl‐2,2‐diphenylvalerate hydrochloride (SKF 525‐A) on sulphacetamide distribution and excretion in rats
Author(s) -
MARCHAND C.,
NADEAU D.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08159.x
Subject(s) - excretion , endocrinology , medicine , distribution (mathematics) , kidney , chemistry , hydrochloride , sodium , pharmacology , biochemistry , mathematical analysis , mathematics , organic chemistry
Summary1 Administration of 2‐diethylaminoethyl‐2,2‐diphenylvalerate hydrochloride (SKF 525‐A), 40 mg/kg, i.p., simultaneously or 40 min before sulphacetamide sodium, 100 mg/kg, i.p., was associated with a three‐fold increase in sulphacetamide plasma concentration of rats. This effect was no longer evident after 30 minutes. 2 The augmentation in sulphacetamide plasma concentration was associated with parallel increases in the muscle, kidney and brain tissue. The stomach was the only organ that contained less sulphacetamide. 3 When sulphacetamide was administered i.v., a similar phenomenon was observed but the differences were less marked. 4 Pretreatment with SKF 525‐A was associated with decreased excretion of sulphacetamide by the kidney. 5 It is concluded that SKF 525‐A may alter the distribution and excretion of drugs as well as inhibiting drug metabolizing enzymes.