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Renin‐like activity of the rat submaxillary gland: characterization and the effect of several drugs and stimuli
Author(s) -
GUTMAN Y.,
LEVY M.,
SHORR J.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08158.x
Subject(s) - submaxillary gland , submandibular gland , endocrinology , renin–angiotensin system , medicine , chemistry , pharmacology , blood pressure
Summary1 Renin‐like activity was found in rat submaxillary glands. 2 This activity was destroyed by boiling, was non‐dialyzable and showed an optimum at approximately 50° C. 3 Renin‐like activity in the submaxillary gland was not diminished 24 h after nephrectomy but was considerably reduced after ligature of the submaxillary duct. 4 Renin‐like activity in the submaxillary gland was reduced following food‐deprivation, water‐deprivation or hypovolemia. 5 Renin‐like activity in the rat submaxillary gland was increased after isoproterenol administration but not following pilocarpine. 6 Renin‐like activity in the rat submaxillary gland was increased considerably by administration of NaCl or KCl, as well as following adrenalectomy. 7 Chlorothiazide and ouabain increased submaxillary renin‐like activity but diazoxide did not affect this activity.