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Some effects of inhibiting endogenous prostaglandin formation on the responses of the cat spleen
Author(s) -
FERREIRA S. H.,
MONCADA S.,
VANE J. R.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08157.x
Subject(s) - prostaglandin , stimulation , endogeny , spleen , endocrinology , medicine , chemistry , prostaglandin e , prostaglandin antagonist , prostaglandin e2 , pharmacology
Summary1 Cat isolated spleens release prostaglandins into the venous effluent in response to stimuli such as nerve stimulation, noradrenaline and angiotensin II. 2 The release of prostaglandins is abolished by pre‐treatment of the spleen with indomethacin (0·3–5 μg/ml). 3 The capsular and vascular responses to the different stimuli are augmented after inhibition of prostaglandin release. 4 The prevention of prostaglandin release, as well as the augmentation of vascular and capsular responses, are reversible after indomethacin treatment is stopped. 5 The role of prostaglandins as modulators of the responses to several stimuli is discussed.