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Behavioural studies of the actions of cocaine, monoamine oxidase inhibitors and iminodibenzyl compounds on central dopamine neurones
Author(s) -
CHRISTIE JANICE E.,
CROW T. J.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08156.x
Subject(s) - nialamide , pargyline , reserpine , dopamine , desipramine , pharmacology , chemistry , monoamine oxidase , tetrabenazine , medicine , endocrinology , antidepressant , biochemistry , hippocampus , enzyme
Summary1 Turning behaviour after unilateral lesions of the nigro‐striatal dopamine pathway in rats has been used to compare the actions of cocaine and desipramine on central dopamine‐containing neurones. 2 Administration of cocaine alone (5–20 mg/kg) resulted in no turning or minimal turning towards the lesioned side; the monoamine oxidase inhibitors nialamide and pargyline administered alone were also ineffective. 3 After pre‐treatment with nialamide (100 mg/kg) or pargyline (25 mg/kg) cocaine evoked high rates of turning towards the lesioned side. 4 Desipramine (1–100 mg/kg), either alone or in combination with nialamide did not evoke turning. 5 Turning evoked by the cocaine‐nialamide combination was abolished by pre‐treatment with α‐methyl‐ p ‐tyrosine (150 mg/kg). 6 Pre‐treatment with reserpine (5 mg/kg, 24 h previously) substantially diminished turning evoked by the cocaine‐nialamide combination but potentiated turning resulting from administration of methylamphetamine (5 mg/kg). 7 Cocaine (20 mg/kg) administered 15 min prior to (+)‐methylamphetamine (5 mg/kg) reduced the turning behaviour in the first hour after administration of the latter drug but prolonged the total duration of the effect.