Premium
Histamine H 2 ‐receptors in the sheep bronchus and cat trachea: the action of burimamide
Author(s) -
Eyre P.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb06920.x
Subject(s) - mepyramine , histamine , metiamide , chemistry , receptor , medicine , endocrinology , pharmacology , histamine h2 receptor , biology , antagonist
Histamine-induced relaxation of the sheep bronchus was antagonized by burimamide but not by mepyramine, indicating the presence of H(2)-receptors. Mepyramine or burimamide alone produced partial antagonism of histamine-induced relaxation of the cat trachea. Both inhibitors added simultaneously effectively abolished the histamine response, suggesting that both H(1)- and H(2)-receptors are active in relaxing the cat trachea.