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Effect of penicillin on the increase in membrane conductance induced by γ‐aminobutyric acid at the crab neuromuscular junction
Author(s) -
Earl Janet,
Large W. A.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb06919.x
Subject(s) - picrotoxin , penicillin , conductance , neuromuscular junction , biophysics , chemistry , antagonist , gamma aminobutyric acid , gaba receptor antagonist , aminobutyric acid , neuroscience , biochemistry , biology , bicuculline , physics , antibiotics , receptor , condensed matter physics
The effects of penicillin and picrotoxin on the increase in membrane conductance produced by gamma-aminobutyric acid (GABA) at the hermit crab neuromuscular junction were investigated. Penicillin failed to block the effects of GABA, while picrotoxin proved to be a potent antagonist.