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The effects on cardiac muscle and nerve of a fluorinated decahydroquinoline derivative, L7810, rapidly absorbed after oral administration
Author(s) -
BAGWELL E. E.,
POLSTER P.,
WILLIAMS E. M. VAUGHAN
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb06904.x
Subject(s) - chronotropic , bradycardia , ouabain , isoprenaline , atropine , procaine , chemistry , inotrope , heart rate , anesthesia , medicine , aconitine , pharmacology , endocrinology , blood pressure , sodium , stimulation , organic chemistry
Summary1 . L7810 (4‐carbamoyloxy‐1‐(4‐(4‐fluorophenyl)‐4‐oxobutyl) decahydroquinoline, has a local anaesthetic action on frog nerve 1·75 times that of procaine. 2 . L7810 protected anaesthetized guinea‐pigs against ouabain‐induced ventricular fibrillation and increased the lethal dose of ouabain. 3 . L7810 reduced the rate of rise of intracellularly recorded action potentials in rabbit isolated atria; the resting potential was not affected, but the duration of the action potential was prolonged. 4 . Unlike most drugs with local anaesthetic properties L7810 did not depress contractions in isolated atria but increased them. 5 . L7810 reduced the spontaneous frequency, maximum follow frequency and conduction velocity of rabbit isolated atria. 6 . L7810 had no blocking action on the chronotropic or positive inotropic actions of isoprenaline on isolated atrial muscle. 7 . In anaesthetized dogs L7810 caused a small dose‐related bradycardia, and a large dose‐related decrease in peripheral vascular resistance. There was no blockade of the effects of isoprenaline on heart rate or peripheral blood flow.