Premium
Degradation of angiotensin II by plasmin
Author(s) -
DUDEK G.,
LATALLO Z. S.,
PROKOPOWICZ J.,
WOROWSKI K.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb09576.x
Subject(s) - plasmin , angiotensin ii , asparagine , chemistry , fibrinolysin , renin–angiotensin system , peptide , biochemistry , chromatography , amino acid , endocrinology , biology , receptor , enzyme , blood pressure
Summary1 . Synthetic angiotensin II (Hypertensin, Ciba, Basel) was incubated with a water‐insoluble preparation of plasmin (E.C. 3.4.4.14) and the resulting products analysed by paper chromatography and N‐terminal amino‐acid analysis. 2 . Only the N‐terminal asparagine was split off from the peptide. This indicates that plasmin attacks the Asn‐Arg but not the Arg‐Val in angiotensin II molecule.