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The presence of β‐adrenoceptors in the guinea‐pig seminal vesicle
Author(s) -
SPEDDING M.,
WEETMAN D. F.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb09572.x
Subject(s) - isoprenaline , guinea pig , propranolol , salbutamol , endocrinology , medicine , seminal vesicle , chemistry , hypogastric nerve , stimulation , adrenergic , biology , receptor , prostate , cancer , asthma
Summary1 . The preparation of longitudinal smooth muscle strips from guinea‐pig seminal vesicles is described. 2 . Isoprenaline and salbutamol inhibited contractions produced by parasympathomimetic agents. 3 . The inhibitory action of isoprenaline was blocked by low concentrations of propranolol and butoxamine. It was concluded that β 2 ‐adrenoceptors were present in the tissue. 4 . The inhibitory action of isoprenaline was not apparent when adrenaline, noradrenaline, hypogastric nerve or transmural stimulation were used to contract the tissue.