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Peripheral cardiovascular effects, in the pithed rat, of compounds used in the treatment of hypertension
Author(s) -
Dhasmana K. M.,
Fokker W. A. B.,
Spilker B. A.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb08148.x
Subject(s) - peripheral , clonidine , methyldopa , medicine , sympathetic nervous system , iproniazid , guanethidine , endocrinology , cardiology , pharmacology , blood pressure , chemistry , biochemistry , stimulation , monoamine oxidase , enzyme
A method for stimulating discrete segments of the spinal autonomic outflow in the pithed rat was found suitable for differentiating between the group of centrally acting antihypertensive agents alpha-methyldopa, clonidine and iproniazid and other antihypertensive compounds which additionally have peripheral vascular effects mediated via the peripheral sympathetic nerves.