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Metabolism of isoprenaline in dog and man
Author(s) -
CONOLLY M. E.,
DAVIES D. S.,
DOLLERY C. T.,
MORGAN C. D.,
PATERSON J. W.,
SANDLER M.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb08143.x
Subject(s) - isoprenaline , metabolite , urine , medicine , endocrinology , metabolism , oral administration , chemistry , pharmacology , stimulation
Summary1 The metabolism of isoprenaline has been studied in man and dog following intravenous and oral or intra‐duodenal administration. 2 Intravenous isoprenaline was excreted largely unchanged in urine in both species. Only one‐third of the radioactivity in urine was in the form of the O ‐methyl metabolite. 3 After oral doses in man or intraduodenal doses in dogs, plasma radioactivity was almost entirely as conjugated isoprenaline and this metabolite accounted for more than 80% of radioactivity in urine. 4 Catechol‐ O ‐methyl transferase may be less important than Uptake 2 in limiting the pharmacological action of isoprenaline. 5 Pharmacological response (heart‐rate increase) was related to plasma concentration of isoprenaline only after rapid intravenous injections. In dogs, following prolonged infusion or intraduodenal doses, heart rate returned to base‐line values when plasma concentrations of isoprenaline were high.