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Central adrenoceptors concerned in the release of adrenocorticotrophic hormone
Author(s) -
Bhargava K. P.,
Bhargava Rani,
Gupta M. B.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb08127.x
Subject(s) - phenylephrine , isoprenaline , endocrinology , medicine , yohimbine , adrenocorticotrophic hormone , stimulation , phentolamine , epinephrine , propranolol , hormone , catecholamine , chemistry , blood pressure , receptor , antagonist
The effect of injecting the alpha-adrenoceptor stimulating drugs adrenaline, noradrenaline and phenylephrine and the beta-adrenoceptor stimulating drug, isoprenaline into the lateral ventricles (i.c.v.) of the brains of dogs on the plasma cortisol concentration was investigated. Adrenaline, noradrenaline and phenylephrine produced a significant rise in the plasma cortisol concentration. Isoprenaline had no effect on the plasma cortisol concentration. The effect of noradrenaline and phenylephrine on the plasma cortisol concentration was completely blocked by yohimbine (i.c.v.). This indicates that the stimulation of central alpha-adrenoceptors can cause the release of adrenocorticotrophic hormone.