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A study of clofazimine in the rat
Author(s) -
CURREY H. L. F.,
FOWLER P. D.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb08126.x
Subject(s) - clofazimine , leprosy , rheumatoid arthritis , medicine , adjuvant , immunology , pharmacology , arthritis , erythema nodosum , tuberculin , erythema , pathology , tuberculosis , disease
Summary1 Clofazimine, an anti‐mycobacterial agent used in the treatment of leprosy, has been reported to be particularly effective in the treatment of acute erythema nodosum leprosum reactions. 2 The present experiments were designed to study in the rat this apparent anti‐inflammatory activity. 3 In doses relatively non‐toxic to the animals clofazimine inhibited both rat adjuvant arthritis and the inflammatory paw swelling following an adjuvant injection. 4 Clofamizine failed to inhibit both the primary antibody response to sheep erythrocytes and the tuberculin skin response. 5 It is concluded that clofazimine exhibits definite anti‐inflammatory (but not immunosuppressive) activity, and that it should be tested in patients with rheumatoid arthritis.