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Factors influencing the adrenergic neurone blocking action of propranolol
Author(s) -
ELIASH SARAH,
WEINSTOCK MARTA
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb08120.x
Subject(s) - propranolol , adrenal medulla , vas deferens , endocrinology , splanchnic nerves , adrenergic , medicine , blocking (statistics) , medulla , chemistry , catecholamine , stimulation , receptor , mathematics , statistics
Summary1 The reversal by propranolol of its own adrenergic neurone blocking effect in the cat can be prevented by cutting the splanchnic nerves or by ligating the adrenal veins. 2 In the absence of secretion from the adrenal medulla the nerve blocking action of propranolol is more complete, but can still be reversed by repeated injections or a constant infusion of adrenaline. 3 Prior treatment with adrenaline or noradrenaline also prevents the development of the blocking action of propranolol in the cat and in the isolated guinea‐pig vas deferens. 4 It is suggested that in the cat, propranolol stimulates the release of catecholamines from the adrenal medulla which antagonize its nerve blocking effect.