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The effect of Kö 1173, a new anticonvulsant agent on experimental cardiac arrhythmias
Author(s) -
ALLEN J. D.,
EKUE J. M. KOFI,
SHANKS R. G.,
ZAIDI S. A.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb08114.x
Subject(s) - procainamide , phenytoin , anesthesia , medicine , anticonvulsant , sinus rhythm , ventricular tachycardia , saline , ouabain , cardiology , epilepsy , chemistry , sodium , organic chemistry , psychiatry , atrial fibrillation
Summary1 The effects of the intravenous injection of Kö 1173, a new anticonvulsant drug, phenytoin and procainamide were studied on three types of cardiac arrhythmia in dogs. 2 Ventricular ectopic beats produced by intravenous injection of adrenaline in anaesthetized dogs respired with halothane were abolished by Kö 1173, 0·6 ± 0·1 mg/kg, phenytoin, 1·1 ± 0·3 mg/kg and procainamide, 4·1 ± 1·8 mg/kg. 3 Ventricular tachycardia was produced in anaesthetized dogs by the intravenous injection of ouabain and the three drugs infused intravenously at 0·2 (mg/kg)/min until sinus rhythm returned. Kö 1173 was effective in 8 out of 9 dogs after a mean dose of 1·3 ± 0·3 mg/kg; phenytoin in all 3 dogs after 2·7 ± 0·6 mg/kg and procainamide in the 3 dogs tested after 16·6 ± 1·3 mg/kg. 4 The intravenous injection of Kö 1173, 80 mg/kg, greatly reduced the number of ventricular ectopic beats occurring in conscious dogs 18–44 h after ligation of the anterior descending branch of the left coronary artery, with a resultant increase in the number of sinus beats. Phenytoin, 8·0 mg/kg, had a similar effect but procainamide was much less effective. 5 These results indicate that Kö 1173 is effective in abolishing experimental cardiac arrhythmias and suggest that its effects should be studied in patients.