Premium
Central and peripheral effects of propranolol and sotalol in normal human subjects
Author(s) -
Lader M. H.,
Tyrer P. J.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb08113.x
Subject(s) - sotalol , propranolol , peripheral , medicine , sedation , anesthesia , heart rate , pulse rate , blockade , cardiology , blood pressure , receptor , atrial fibrillation
No unequivocal central effects were found with either +/--propranolol (120 mg) or +/--sotalol (240 mg) in acute dosage in normal subjects. Subjective feelings of drowsiness and muzziness were found with sotalol and both sotalol and propranolol caused subjects to feel more troubled. These changes were not accompanied by physiological or behavioural evidence of sedation. Adequate beta-adrenoceptor blockade was achieved as measured by a significant fall in pulse-rate on both active drugs but no other significant peripheral physiological changes occurred.