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A quantitative study of the anticholinergic action of several tricyclic antidepressants on the rat isolated fundal strip
Author(s) -
ATKINSON J.,
LADINSKY H.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb08109.x
Subject(s) - tricyclic , anticholinergic , medicine , pharmacology , scopolamine , action (physics) , anesthesia , parasympatholytics , quantum mechanics , physics
Summary1 Investigations were carried out on the antagonism of the action of carbamylcholine chloride on the isolated fundus of the rat stomach by several tricyclic antidepressants. 2 The anticholinergic potency of the compounds was in the order: GP 45437>amitriptyline>protriptyline>desmethylimipramine>opipramol. All of the antagonists were less effective than atropine. 3 Statistical analysis was carried out to determine whether the theory of competitive antagonism would fit the data obtained.