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Fibrinolytic activity evoked in the plasma of the normal and adrenalectomized rat by cellulose sulphate
Author(s) -
ROSA A. T.,
ROTHSCHILD A. M.,
ROTHSCHILD Z.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb08103.x
Subject(s) - endocrinology , cellulose , medicine , chemistry , biochemistry
Summary1 Cellulose sulphate, a kinin‐releasing agent, produced fibrinolytic activity in plasma when administered intravenously to the rat but not when added to fresh rat plasma in vitro. The in vivo effect was maximal within 1 min and disappeared within 10–20 minutes. It was retained in plasma taken 1 min after the injection and kept at room temperature for 30 minutes. 2 A decrease of anti‐fibrinolytic potency measured against urokinase‐activated bovine plasmin, was shown to occur in plasma of rats given cellulose sulphate. 3 Activated rat plasma lysed heat‐denatured fibrin: it probably contains free plasmin as well as plasminogen activator. 4 Adrenalectomized rats did not exhibit fibrinolytic activity nor statistically significant benzoyl‐arginine ethyl ester‐esterase activation in plasma after cellulose sulphate treatment. 5 Adrenalectomized rats had significantly increased levels of plasma kininogen, but were normally sensitive to the kininogen‐depleting action of cellulose sulphate. 6 The increased plasma kininogen of adrenalectomized rats seems to be a consequence of the impairment of the plasminogen activating mechanism.