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A metabolic interaction in vivo between cannabidiol and Δ 1 ‐tetrahydrocannabinol
Author(s) -
Jones G.,
Pertwee R. G.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb08092.x
Subject(s) - cannabidiol , delta 9 tetrahydrocannabinol , tetrahydrocannabinol , chemistry , metabolite , cannabinol , in vivo , δ9 tetrahydrocannabinol , catalepsy , pharmacology , cannabinoid , biochemistry , medicine , biology , cannabis , dopamine , microbiology and biotechnology , receptor , psychiatry , haloperidol
The effect of pretreatment with cannabidiol (CBD; 50 mg/kg i.p.) on the distribution of radioactivity in chromatograms of ethyl acetate extracts of the brains of mice injected with tritiated Delta(1)-tetrahydrocannabinol ((3)H-Delta(1)-THC; 1.0 mg/kg i.v.) was determined. The pretreatment with CBD produced significant increases in the levels of radioactivity in the brain assigned to Delta(1)-THC and its centrally active metabolite 7-hydroxy-Delta(1)-THC: the changes produced were respectively 1.4 and 2.0 fold.Pretreatment with CBD did not bring about any detectable change in the degree of 'catalepsy' produced by Delta(1)-THC. This negative finding may have been due to the wide limits of error that were obtained in the bioassay.