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Comparison of the dose‐response effects of morphine on brain amines, analgesia and activity in mice
Author(s) -
FENNESSY M. R.,
LEE J. R.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb08079.x
Subject(s) - morphine , dopamine , chemistry , monoamine neurotransmitter , pharmacology , analgesic , serotonin , dose–response relationship , endocrinology , medicine , biochemistry , receptor
Summary1 Noradrenaline, dopamine, 5‐hydroxytryptamine and 5‐hydroxyindoleacetic acid concentrations in the mouse brain were measured 30 min after subcutaneous injection of doses of morphine ranging from 01 to 100 mg/kg: motor activiy was also measured. 2 The noradrenaline concentration in the mouse brain was reduced by moderate (2 to 20 mg/kg) but not by high (above 20 mg/kg) and low (below 2 mg/kg) doses of morphine. 3 The dopamine concentration in the mouse brain was reduced by moderate (1 to 20 mg/kg) doses but was raised by high doses (above 20 mg/kg) of morphine. 4 The 5‐hydroxytryptamine concentration in the mouse brain was reduced by moderate (1 to 20 mg/kg) doses of morphine but not by high (above 20 mg/kg) and low (below 1 mg/kg) doses of morphine. 5 The 5‐hydroxyindoleacetic acid concentration was not affected by low doses (01 to 2 mg/kg), raised by a dose of 5 mg/kg, lowered by doses of 10–50 mg/kg and not affected by 100 mg/kg of morphine. 6 These results are discussed with reference to the possible implication of changes in monoamines for the analgesic and behavioural effects of morphine.