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A comparison of the haemodynamic effects of propranolol, 4‐hydroxypropranolol and practolol in anaesthetized dogs
Author(s) -
FITZGERALD J. D.,
O'DONNELL STELLA R.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb08076.x
Subject(s) - practolol , propranolol , heart rate , hemodynamics , blood pressure , chronotropic , cardiac output , anesthesia , medicine
Summary1 The haemodynamic effects of propranolol, practolol and 4‐hydroxypropranolol have been compared in anaesthetized dogs both at free heart rates and at heart rates fixed by electrical pacing. All three drugs produced a fall in heart rate at the lowest dose of 009 mg/kg. 2 Practolol caused less change in d P /d t , cardiac output and blood pressure than did propranolol. 4‐Hydroxypropranolol had intermediate effects. Since the changes in d P/d t caused by these three drugs were still present when the heart rate was fixed by pacing, it is concluded that these were independent of changes in heart rate. 3 The fact that practolol and 4‐hydroxypropranolol cause less change in haemodynamic function than propranolol may be associated with the intrinsic sympathomimetic activity possessed by the first two of these drugs.