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Central cholinergic and adrenergic mechanisms in the release of antidiuretic hormone
Author(s) -
BHARGAVA K. P.,
KULSHRESTHA V. K.,
SRIVASTAVA Y. P.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb07301.x
Subject(s) - phenoxybenzamine , endocrinology , medicine , propranolol , antidiuretic , isoprenaline , diuretic , chemistry , atropine , vasopressin , stimulation
Summary1 Studies on the urine outflow, blood ADH concentration and electrolyte excretion were carried out in α‐chloralose anaesthetized hydrated dogs; the agonists and antagonists of specific cholinoceptors and adrenoceptors were injected by the intracerebroventricular technique, to delineate the role of the C.N.S. receptors in the control of ADH secretion. 2 Central injection of acetylcholine elicited a dose‐dependent antidiuretic response which was associated with an increase in the blood ADH titre. Central atropinization partially blocked the antidiuretic response. The remaining antidiuretic response was reversed to a diuretic one by further pretreatment with phenoxybenzamine. The diuretic response thus obtained could be blocked by propranolol. 3 The α‐adrenoceptor agonists, phenylephrine and noradrenaline, induced dose‐dependent antidiuretic responses with a concomitant rise in blood ADH concentration. Their effect could be blocked by pretreatment centrally with phenoxybenzamine. Low doses of adrenaline induced a diuretic response and a decrease in blood ADH concentration, higher doses elicited a dose‐dependent antidiuretic response and increase in the titre of ADH in blood. Central phenoxybenzamine pretreatment reversed the antidiuretic effect of high doses of adrenaline to a diuretic effect which could be blocked by propranolol. 4 Isoprenaline elicited a dose‐dependent diuretic response and a decrease in blood ADH titre and propranolol competitively blocked the effect of isoprenaline. 5 It is concluded that central muscarinic cholinoceptors and the α‐adrenoceptors are concerned in the release of ADH, whereas the β‐adrenoceptors are concerned with inhibition of ADH release.