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Effects of gamma‐hydroxybutyrate on chick behaviour, electrocortical activity and crossed extensor reflexes
Author(s) -
OSUIDE GABRIEL
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb07299.x
Subject(s) - picrotoxin , strychnine , convulsant , gamma hydroxybutyrate , long term potentiation , neuroscience , reflex , anticonvulsant , convulsants , anesthesia , pharmacology , epilepsy , medicine , psychology , receptor , antagonist
Summary1 Convulsant and anticonvulsant effects of gamma‐hydroxybutyrate (GHB) have been studied in chicks. 2 When administered alone, GHB produced weak myoclonic seizures accompanied by electrocortical synchrony and spikes. 3 GHB was found to protect chicks against leptazol‐ and picrotoxin‐induced seizures. A slight potentiation of strychnine‐induced seizures was evident.