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Excretion of 14 C‐edrophonium and its metabolites in bile: role of the liver cell and the peribiliary vascular plexus
Author(s) -
BACK D. J.,
CALVEY T. N.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb07290.x
Subject(s) - edrophonium , glucuronide , endocrinology , excretion , chemistry , medicine , metabolism , pharmacology , myasthenia gravis
Summary1 The metabolism and biliary excretion of 14 C‐edrophonium chloride was studied in Wistar rats. 2 Approximately 5% of the dose was recovered from bile in 6 hours. Most of the radioactivity was eliminated as 14 C‐edrophonium glucuronide. Small amounts of the unchanged drug were also detected in bile, particularly during the first hour after administration of the drug. 3 The concentration of 14 C‐edrophonium glucuronide in bile was approximately 15–20 times its concentration in plasma. 4 In contrast, the concentration of unchanged 14 C‐edrophonium was similar in bile and plasma. 5 Evidence is presented that unchanged 14 C‐edrophonium is transferred from plasma to bile via the peribiliary vascular plexus.