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Selective inhibition by glycine of some somatic reflexes in the cat
Author(s) -
DHAWAN B. N.,
SHARMA J. N.,
SRIMAL R. C.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb07279.x
Subject(s) - strychnine , glycine , reflex , reticular formation , stimulation , glycine receptor , cats , withdrawal reflex , chemistry , anesthesia , pharmacology , endocrinology , medicine , biochemistry , amino acid
Summary1 The effects of intracerebroventricular or intrathecal administration of glycine on some somatic reflexes in chloralosed cats were investigated. 2 Glycine produced marked inhibition of the flexor reflex (FR) and crossed extensor reflex (CER) at low doses (2·5–5·0 mg) but even large doses (up to 400 mg) had no effect on the facilitation or inhibition of the patellar reflex produced by stimulation of either the reticular formation or the sciatic nerve. The linguomandibular reflex (LMR) could be blocked by 10–20 mg glycine. 3 Glycine antagonized strychnine‐induced facilitation of FR, CER and LMR and was 5–6 times as active as γ‐aminobutyric acid in this respect. 4 The possibility of glycine being a transmitter in spinal pathways is discussed.