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Some pharmacological properties of piperazine
Author(s) -
MASON P. A.,
STURMAN GILLIAN
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb07252.x
Subject(s) - piperazine , atropine , stimulation , contraction (grammar) , skeletal muscle , heart rate , cardiac muscle , muscle contraction , endocrinology , chemistry , pharmacology , medicine , anesthesia , blood pressure
Summary1 The action of piperazine on mammalian smooth, cardiac and skeletal muscles has been studied. 2 Piperazine increased tone and produced a dose dependent contraction of isolated smooth muscle, which was antagonized by atropine. 3 With cardiac muscle, piperazine depressed both the rate and force of contraction and was antagonized by atropine. At higher concentrations, a non‐specific depression of cardiac muscle was found. The intravenous injection of piperazine produced a transient decrease in both heart rate and blood pressure and this was followed by an increase. 4 In about half of the mammalian skeletal muscle preparations, piperazine potentiated the twitch of the muscle evoked by electrical stimulation. 5 On the frog neuromuscular preparation, piperazine produced potentiation of the twitch but this was followed first by blockade of the effects, of nerve stimulation and then by depression of the effects of direct muscle stimulation.