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Abolition of the nerve‐induced responses of the isolated vas deferens of the young rat by agents blocking α‐adrenoceptors
Author(s) -
SWEDIN G.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb07248.x
Subject(s) - vas deferens , atropine , long term potentiation , endocrinology , medicine , blocking (statistics) , chemistry , receptor , statistics , mathematics
The mechanical responses of isolated fieldstimulated vasa deferentia from rats 3-10 days old were abolished by low doses of drugs blocking alpha-adrenoceptors. In preparations from older animals this effect was absent or there was a potentiation of the responses. The effect of atropine also changed during postnatal development. In the early period a moderate (10-40%) decline of the nerve-induced responses was generally observed, but later even high concentrations of atropine were without effect.