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Anterograde amnesic effects of pethidine, hyoscine and diazepam in adults
Author(s) -
DUNDEE J. W.,
PANDIT S. K.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb07245.x
Subject(s) - amnesia , anterograde amnesia , diazepam , pethidine , retrograde amnesia , anesthesia , medicine , saline , psychology , psychiatry , analgesic
Summary1 The intravenous administration of 5 and 10 mg of diazepam caused anterograde amnesia in 50 and 90% of adults, the peak effect occurring in 2–3 min and action persisting for 20–30 minutes. 2 Hyoscine (0·4 and 0·6 mg) caused amnesia in 35 and 50% of patients with peak effect not occurring until 50–80 min after injection and action persisting for at least 120 minutes. 3 With neither drug was there any relationship between the incidence of amnesia and the degree of drowsiness. 4 Amnesia was not observed after saline or after 50 mg pethidine. 5 On questioning 6 h after a short operation many patients had no memory of an object which they clearly recognized and described 1 h after surgery.