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Quantitative analysis on isolated organs of the autonomic blocking properties of indoramin hydrochloride (Wy 21901)
Author(s) -
ALPS B. J.,
HILL MADELINE,
JOHNSON E. S.,
WILSON A. B.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb07237.x
Subject(s) - ileum , pharmacology , chemistry , vas deferens , antagonism , propranolol , schild regression , medicine , endocrinology , receptor
Summary1 Indoramin is a competitive α‐adrenoceptor blocking agent on the guinea‐pig isolated vas deferens and aortic strip; the pA 2 value on the aorta is 7·4. 2 Indoramin is devoid of β‐adrenoceptor blocking activity on the guinea‐pig isolated trachea (10 – 4 m ) and the Langendorff preparation of the rabbit heart (10 −6 m ). It also has no adrenergic neurone blocking action on the Finkleman preparation of the rabbit small intestine (10 −5 m ). 3 On the Langendorff preparation of the rabbit isolated heart, indoramin (above 10 −6 m ) has cardio‐inhibitory properties similar to those of propranolol. 4 On the guinea‐pig isolated ileum (10 −5 m ) and trachea (10 −6 m ), indoramin is devoid of anticholinergic activity, but has a potent antihistamine action which satisfies the criteria for competitive antagonism; the pA 2 value for this antagonism on the ileum is 8·2. 5 Indoramin antagonizes 5‐hydroxytryptamine on the rat isolated fundus and ileum; the pA 2 value for the antagonism on the ileum is 60.