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Pharmacological properties of amino‐oxyacetic acid in the chicken
Author(s) -
OSUIDE G.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb07235.x
Subject(s) - chemistry , neuroscience , biology , medicine
Summary1 The effects of amino‐oxyacetic acid (AOAA) on the central nervous system and on skeletal muscle have been examined in the chicken. 2 AOAA had both anticonvulsant and convulsant effects, depending on the dose, as in other species. 3 The convulsant effect, accompanied by EEG spiking, decreased rapidly with increase in age of young chicks. 4 The convulsant effect was exerted primarily through supraspinal centres. 5 Of control depressants tested, only troxidone and small doses of AOAA afforded significant protection against AOAA seizures.