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A new example of a morphine‐sensitive neuro‐effector junction: adrenergic transmission in the mouse vas deferens
Author(s) -
Henderson G.,
Hughes J.,
Kosterlitz H. W.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb06901.x
Subject(s) - adrenergic , effector , clinical pharmacology , medicine , morphine , citation , computer science , library science , pharmacology , receptor , immunology
The isolated mouse vas deferens possesses an adrenergic excitatory motor innervation which can be inhibited by low concentrations of morphine (ID50=0.5 muM). This effect of morphine is mediated by specific receptors which are blocked by naloxone. Activation of the morphine receptors inhibits noradrenaline release. It is concluded that adrenergic neurotransmission in the mouse vas deferens differs in some important way from that at the more common, morphine-insensitive, adrenergic junctions.