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The effect of phospholipids on anaphylactic histamine release
Author(s) -
MONGAR J. L.,
SVEC P.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb06899.x
Subject(s) - histamine , anaphylaxis , liberation , chemistry , pharmacology , medicine , biochemistry , immunology , allergy , in vitro
Summary1 . Histamine release by antigen from three sensitized rat tissues is potentiated by phosphatidyl serine (PS). The effect is greatest with isolated peritoneal cells. Phosphatidyl inositol, ethanolamine, choline and phosphatidic acid are inactive. 2 . PS greatly increases the rate of antigen‐induced histamine release and only slightly prolongs the duration of the release process. 3 . PS shows a concentration‐dependent effect over the range 1–10 μg/ml. At 10 μg/ml it is active over a wide range of antigen concentrations. 4 . Calcium ions are necessary for the potentiation by PS of antigen‐induced histamine release from rat peritoneal cells.