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Effect of chronic drug treatment on intestinal membrane transport of 14 C‐ l ‐DOPA
Author(s) -
RIVERACALIMLIM LEONOR
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb06895.x
Subject(s) - chlorpromazine , neomycin , amantadine , pharmacology , membrane transport , drug , chemistry , medicine , endocrinology , biochemistry , membrane , antibiotics
Summary1 . By the use of the everted jejunal sac it was shown that chronic oral treatment of rats with various drugs can either increase or decrease the mucosal transport of 14 C‐ l ‐DOPA or alter its serosal/tissue ratio. 2 . 14 C‐ l ‐DOPA transport was significantly increased in rats that were chronically treated with l ‐DOPA and diminished in those that were treated with chlorpromazine and phenobarbitone. 3 . Chronic treatment with amantadine and neomycin did not affect 14 C‐ l ‐DOPA intestinal transport, although direct addition of amantadine to the medium, significantly increased 14 C‐ l ‐DOPA transport in everted sacs of non‐treated rats. Addition of neomycin directly to the medium did not affect 14 C‐ l ‐DOPA transport. 4 . The possible mechanisms of these findings and their clinical significance are discussed.