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Enhancement of noradrenaline depletion in the cat spleen by phenoxybenzamine and phentolamine
Author(s) -
Cripps Heather,
Dearnaley D. P.,
Howe P. R. C.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb06883.x
Subject(s) - phenoxybenzamine , phentolamine , endocrinology , medicine , chemistry , stimulation , spleen , nerve stimulation , propranolol
The noradrenaline content of the microsomal fraction of cat spleen was reduced by nerve stimulation. The reduction was greater in the presence of phenoxybenzamine and phentolamine, but was not affected by the presence of cocaine. The results suggest that phenoxybenzamine and phentolamine are able to increase the impulse-evoked release of noradrenaline.