Premium
The effect of betahistine on gastric acid secretion and mucosal blood flow in conscious dogs
Author(s) -
Curwain B. P.,
Holton Pamela,
Spencer Jan
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb06881.x
Subject(s) - betahistine , histamine , blood flow , secretion , gastric acid , medicine , endocrinology , chemistry , surgery , vertigo
In 3 conscious dogs, betahistine (2-(2'-methyl aminoethyl pyridine)) (80 or 160mug kg(-1) min(-1)) increased acid secretion from Heidenhain pouches to 8.8% and 17.6% respectively of the maximal response to histamine. Betahistine also increased mucosal blood flow (radioactive aniline clearance). The ratio of mucosal blood flow to secretion was greater for betahistine than for histamine but the difference between betahistine and histamine was significant in only one of the dogs.