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Effect on reproductive organs of three clomiphene analogues
Author(s) -
BASU J.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb06877.x
Subject(s) - potency , beta (programming language) , stereochemistry , chemistry , nitro , medicinal chemistry , endocrinology , medicine , pharmacology , biochemistry , in vitro , alkyl , organic chemistry , computer science , programming language
Summary1 . The oestrogenic properties of four triphenylethylene compounds were compared. They can be listed as follows in order of their oestrogenic potency: 1‐[ p ‐(β‐diethylaminoethoxy)‐phenyl]‐2‐nitro‐1,2‐diphenylethylene (E.I.P.W. 111) > clomiphene > 1‐[ p ‐(β‐dimethylaminoethoxy)‐phenyl]‐2‐nitro‐1,2‐diphenylethylene (E.I.P.W. 113)>1‐[ p ‐(β‐diethylaminoethoxy)‐phenyl]‐1,2‐diphenylethylene (E.I.P.W. 103). The oestrogenic potency of compound E.I.P.W. 111 was found to be about 1/10th of that of oestradiol. 2 . Compound E.I.P.W. 111 is partially antioestrogenic but not progesteronic in nature. It has no androgenic effect.