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Pharmacokinetic and toxicological studies of antimony dextran glycoside (RL‐712)
Author(s) -
CASALS J. BOU
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb06873.x
Subject(s) - excretion , urine , glycoside , antimony , toxicity , pharmacology , spleen , chemistry , absorption (acoustics) , pharmacokinetics , body weight , toxicokinetics , dextran , endocrinology , medicine , biology , chromatography , biochemistry , stereochemistry , inorganic chemistry , physics , acoustics
Summary1 . The absorption, tissue distribution and excretion of antimony dextran glycoside (RL‐712) has been studied in normal rodents. 2 . Some organs in the body, especially liver and spleen, retain large amounts of antimony for considerable periods of time. Excretion of antimony in the urine was low and only about 10–12% of the dose administered was excreted within the first 48 hours. 3 . Blood levels were maintained for at least 3 days after a single intramuscular dose to rabbits, corresponding to 14 mg Sb/kg body weight. 4 . Toxicity studies and tests on foetal toxicity in mice and rats, respectively, showed no abnormalities. 5 . The possible value of RL‐712 in the prophylaxis and treatment of leishmaniasis is discussed.