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Prostaglandin biosynthesis by human skin and its inhibition by corticosteroids
Author(s) -
Greaves M. W.,
McDonaldGibson Wendy
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb06861.x
Subject(s) - fluocinolone acetonide , biosynthesis , prostaglandin , arachidonic acid , endocrinology , medicine , chemistry , steroid biosynthesis , prostaglandin e , human skin , steroid , pharmacology , biochemistry , enzyme , biology , hormone , dermatology , genetics
Homogenates of human breast skin form prostaglandins E(2) and F(2alpha) in the presence of arachidonic acid substrate. Significant inhibition of biosynthesis of prostaglandin E(2) and F(2alpha) was observed in the presence of the anti-inflammatory corticosteroid fluocinolone acetonide. This effect was dose-related. By contrast no significant inhibition was observed in the presence of an approximately equimolar concentration of hydrocortisone.Since prostaglandins have been recovered from several types of inflammatory reactions and are capable of mediating most of the components of inflammation the possibility arises that corticosteroids may owe their anti-inflammatory activity at least in part to inhibition of prostaglandin biosynthesis.