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Experimentally induced automatism in rat isolated ventricle
Author(s) -
Jalón P. D. Garcia,
Moratinos J. P.,
Serrano J. S.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb06859.x
Subject(s) - automatism (medicine) , ventricle , neuroscience , medicine , psychology , cardiology
Exposure to isoprenaline plus electrical stimulation of the isolated right ventricle of the rat produces stable ventricular automatic activity of various types. The incidence of these different types of ventricular arrhythmia is tabulated and analysed. The technique allows the antiarrhythmic activity of drugs to be studied at cellular level where extracardiac factors are excluded.