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Inhibitory and stimulatory effects of secretin on gastric secretion in conscious rats
Author(s) -
JOHANSSON IRENE,
LUNDELL L.,
SVENSSON S. E.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb06852.x
Subject(s) - secretin , secretion , gastric secretion , endocrinology , gastric acid , medicine , secretin family , chemistry , neuroscience , biology , neuropeptide , receptor , vasoactive intestinal peptide
Summary1 . The effect of pure secretin on gastrin‐induced secretion has been studied in conscious rats with Pavlov or Heidenhain pouches. 2 . Rapid intravenous injection of secretin did not inhibit a plateau secretion of acid in the Heidenhain pouch, but infusion of the same amount of secretin over two hours inhibited secretion in both Heidenhain and Pavlov pouches. 3 . A rapid intravenous injection of secretin before the onset of gastrin infusion enhanced the acid secretory response to gastrin in both types of pouches. 4 . Secretin stimulated pepsin secretion.