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The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat
Author(s) -
CHURCH M. K.,
COLLIER H. O. J.,
JAMES G. W. L.
Publication year - 1972
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1972.tb06848.x
Subject(s) - bronchoconstriction , mepyramine , dexamethasone , propranolol , atropine , medicine , bronchospasm , methysergide , asthma , endocrinology , pharmacology , anesthesia , serotonin , antagonist , receptor
Summary1 . A method for the measurement of anaphylactic bronchoconstriction in the rat is described. 2 . Dexamethasone inhibited this response in a dose‐related manner. 3 . Disodium cromoglycate antagonized the response. A bell‐shaped dose‐response curve was obtained with peak activity at 1 mg/kg i.v. 4 . Meclofenamate was not active when given alone or in combination with dexamethasone. 5 . Methysergide significantly inhibited the response. Mepyramine, atropine, propranolol and adrenalectomy did not significantly modify the response. 6 . The relationships of anaphylactic bronchoconstriction in the rat to anaphylactic bronchoconstriction in the guinea‐pig and to human asthma are discussed.