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Effect of aminoguanidine, chlorpromazine and NSD‐1055 on gastric secretion and ulceration in the Shay rat
Author(s) -
Radwan A. G.,
West G. B.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb09946.x
Subject(s) - chlorpromazine , gastric secretion , medicine , stomach , secretion , ligation , gastric acid , gastroenterology , chemistry , endocrinology , pharmacology
Both chlorpromazine and NSD‐1055 (a non‐steroidal anti‐inflammatory drug) markedly lower the volume and acidity of gastric contents of rats subjected to pyloric ligation (Shay technique) and reduce the degree of ulceration in the stomach. On the other hand, aminoguanidine (an inhibitor of histaminase) has no effect on acid secretion or ulceration in these animals.