Premium
Effect of β‐adrenoceptive blocking agents on the response to bronchoconstrictor drugs in the guinea‐pig air overflow preparation
Author(s) -
BURDEN D. T.,
PARKES M. W.,
GARDINER D. G.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb09942.x
Subject(s) - practolol , propranolol , guinea pig , methacholine , phenoxybenzamine , anesthesia , medicine , blockade , pharmacology , lung , respiratory disease , receptor
Summary1 Propranolol augmented the bronchoconstrictor response to methacholine or histamine, recorded by air overflow in the anaesthetized, vagotomized guinea‐pig. 2 After adrenalectomy, propranolol was still active, though less so than before. 3 In the pithed guinea‐pig, there was no augmentation of the effect of bronchoconstrictors on air overflow. The action of propranolol could thus be due to the β‐adrenoceptor blockade of compensatory sympathetic bronchodilator activity, as concluded by McCulloch, Proctor & Rand (1967). 4 Electrical stimulation of the thoracic region of the spinal cord of the pithed guinea‐pig reduced the effect of bronchoconstrictors on air overflow. This reduction could be blocked by propranolol; practolol was much less effective.