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Cutaneous reactions to intradermal prostaglandins
Author(s) -
CRUNKHORN PEARL,
WILLIS A. L.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb09934.x
Subject(s) - histamine , methysergide , mepyramine , chemistry , bradykinin , prostaglandin e , intradermal injection , vascular permeability , endocrinology , mast cell , prostaglandin , medicine , metiamide , pharmacology , immunology , biochemistry , antagonist , receptor , histamine h2 receptor
Summary1 The effects of intradermally injected prostaglandins (PGs) E 1 , E 2 , F 1α and F 2α have been examined in the rat and in man. 2 PGE 1 and PGE 2 caused an increase in local vascular permeability in rat skin; their potency was comparable with that of other putative mediators of inflammation (histamine, bradykinin, and 5 ‐hydroxytryptamine), but PGF 1α and PGF 2α were only slightly active even at a dose of 1 μg. 3 Prior administration of mepyramine and methysergide, or depletion of skin mast cell amines with compound 48/80, indicated that PGE 2 exerted its permeability effect in the rat by a release of mast cell amines. 4 Nanogramme doses of PGE 1 and PGE 2 or microgramme doses of PGF 1α and PGF 2α injected intradermally into the human forearm induced weal and flare responses. 5 It is concluded that prostaglandins E 1 and E 2 can act as intermediates in the production of hyperaemia and oedema resulting from cell damage in the rat and man.