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Inhibition of contact sensitivity in the mouse by topical application of corticosteroids
Author(s) -
EVANS D. P.,
HOSSACK MARGARET,
THOMSON D. S.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb08071.x
Subject(s) - fluocinolone acetonide , triamcinolone acetonide , betamethasone , oxazolone , corticosteroid , pharmacology , hydrocortisone , medicine , contact dermatitis , chemistry , picryl chloride , endocrinology , dermatology , ophthalmology , immunology , allergy , immune system
Summary1 Topical application of oxazolone to the ears of mice previously sensitized to this hapten resulted in a marked increase in ear weight 24 h later. 2 Topical application of hydrocortisone, betamethasone 17‐valerate, fluocinolone acetonide or triamcinolone acetonide inhibited this response in a dose dependent manner. 3 The free alcohols of the three fluorinated compounds were only weakly active. 4 Activity in this model was truly local. Oral administration of hydrocortisone or fluocinolone acetonide at doses comparable to those used topically failed to inhibit the ear swelling. 5 Some steroids with poor anti‐inflammatory properties had no significant effect.